Swine zoonoses, caused by pathogens such as bacteria, viruses, and parasites, pose significant public health and economic risks, particularly in regions with intensive pig farming. Key zoonotic diseases include brucellosis, leptospirosis, salmonellosis, and influenza. Despite advancements in pathogen control, the persistence of zoonotic pathogens and increasing antimicrobial resistance necessitate robust biosecurity, vaccination, and surveillance measures. Biosecurity practices, including controlled farm access, visitor management, and quarantine protocols, are critical for preventing disease transmission and reducing antibiotic use. Vaccination complements these measures by preserving herd health and minimizing zoonotic outbreaks. Surveillance systems enable early detection and effective management of diseases, supported by diagnostic tools, comprehensive health screenings, and accurate record-keeping. Additionally, vector control strategies targeting rodents, insects, and other carriers are essential to mitigate pathogen transmission. These integrated approaches align with the One Health framework, emphasizing the interconnectedness of animal, human, and environmental health, to ensure sustainable swine production and protect public health. Preventing disease in pig farms requires vector control, sanitation, biosecurity, and waste management. Key measures include integrated pest management, proper hygiene, manure handling, and regular cleaning. Biosecurity protocols and staff training ensure early disease detection and control. Effective waste management and compliance with environmental regulations minimize health risks and promote sustainability.