Clinical symptoms of the infectious disease erysipelas include fever, arthritis, skin lesions, and abrupt death. It primarily affects growing pigs. The disease could be subacute, acute, or chronic. A particular microorganism called Erysipelothrix rhusiopathiae, a zoonotic, prevalent, gram-positive bacterium is the cause of erysipelas in swine, birds, and mammals as well as Erysipeloid in humans. Those who come into contact with animals, animal byproducts, or animal waste are most vulnerable. Some pig infections, including African swine fever, that present with acute symptoms like abrupt mortality could have been mistaken for the acute form of swine erysipelas. Clinical indications, necropsy findings, antimicrobial response, bacteriology, and molecular and serological tests can all be used to diagnose it. It is advised to increase awareness of the disease among animal and human practitioners as treatment is easy and readily available and vaccination is possible. However, local lab workers, butchers, meat inspectors, clinical physicians, and veterinarians are still unaware of the disease. Promoting good cleanliness, routine pork inspections, and the use of protective gear by anyone who deals with or comes into touch with animals is important. Being a serious zoonotic disease, the disease has a negative impact on public health and generates significant economic losses in pig-producing areas. Therefore, the chapter aims to improve understanding of this disease to properly handle and prevent it from spreading.