The global transportation industry heavily depends on traditional fuel consumption. It accounts for over 50% of total conventional liquid fuels. This reliance has contributed significantly to CO2 emissions, with transportation alone responsible for nearly a quarter of total CO2 output. To achieve sustainable transportation, e-fuels present a viable alternative to mitigate the adverse effects of CO2 emissions from the combustion of fossil fuels, which have been significantly depleted due to excessive usage. E-fuels, known as carbon–neutral synthetic fuels, are produced using renewable electricity for water electrolysis to generate hydrogen and utilize CO2 from biomass or industrial emissions through the Fischer–Tropsch process, resulting in various e-fuels. Substituting conventional fuels with e-fuels directly reduces emissions from transportation facilities. Hydrogen and alcohol due to their lower carbon content are suitable categories of e-fuels. This chapter focuses on the pyrolysis and oxidation chemistry of potential e-fuels, including methanol, ethanol, and propanol. It examines their ignition delay time characteristics. These characteristics are compared to methane, ethane, propane, ethene, and propene. The goal is to assess the suitability of these e-fuels for use in combustion chambers. Additionally, it includes reaction path flow diagrams and sensitivity analysis to understand the oxidation chemistry and identify chain-promoting and inhibiting reactions in the mechanism. It provides an introduction and overview of alcohol and alkane combustion by modeling the results with robust chemical kinetic mechanisms.