The chapter provides a comprehensive examination of the different fuel injection methodologies employed to optimize the use of methanol in Internal Combustion (IC) engines. As the global focus intensifies on sustainable energy sources, methanol emerges as a promising alternative to conventional fossil fuels, necessitating refined injection techniques to enhance performance, efficiency, and emissions characteristics of the IC engines. This chapter delves into multiple strategies, including blending, Port Fuel Injection (PFI), high-pressure direct injection (HPDI), and emulsions, each tailored to maximize the advantages of methanol while addressing their inherent challenges. In this chapter, blending involves the mixture of methanol with conventional fuels, facilitating a seamless transition and compatibility with existing engine technologies. PFI, a widely used technique, introduces methanol into the intake port, promoting homogeneous mixing and improved combustion stability. HPDI, on the other hand, directly injects methanol into the combustion chamber under high pressure, offering precise control over the injection process, thereby enhancing combustion efficiency and reducing emissions. The chapter also explores the use of emulsions, where methanol is combined with water or other fluids to form a stable mixture, resulting in a more complete combustion process and significant emission reductions. This chapter also aims to thoroughly review different fuel injection strategies, such as adjusting injection pressure, altering injection timing, and implementing multiple injections, to enhance engine performance and control emissions. Each section provides an in-depth analysis of the operational principles, advantages, and limitations of these techniques, supported by recent research findings and case studies. In conclusion, the chapter underscores the critical role of innovative fuel injection technologies in the broader adoption of methanol, highlighting their potential to transform the energy landscape by providing cleaner, more efficient, and sustainable fuel options for IC engines.