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Epidemiological studies have demonstrated that individuals exposed to formaldehydeFormaldehyde exhibit a range of neuropsychiatric symptoms, encompassing disturbances in circadian rhythm, disrupted sleep patterns, anxietyAnxiety, depressionDepression, and anorexia. Meta-analyses and bioinformatics methodologies provide compelling evidence and plausible biological explanations for the link between formaldehyde exposure and brain disorders. Except for exogenous exposure, psychiatric disorders may also be associated with endogenous formaldehydeEndogenous formaldehyde accumulation resulting from impaired metabolism induced by aging or diseases. Elevated exogenous or endogenous formaldehydeEndogenous formaldehyde level leads to increased concentrations of formaldehyde (or formic acid) in patients’ urineUrine, which can be used as a predictive marker for certain neuropathological conditions. Herein, we propose that the formaldehyde cycle may act as a regulator of circadian rhythm by influencing the metabolism of melatonin (MT)Melatonin (MT), norepinephrine, epinephrine, and serotonin. The S-adenosyl-L-methionine (SAM)/S-adenosyl-L-homocysteine (SAH) ratio shows circadian rhythms, with formaldehyde acting as a donor of methyl group and participating in the methylation of histone, DNA and RNA. We also discuss the impacts of formaldehyde exposure on psychosomatic and neuropathological behaviorsBehaviors, including sleep disturbances, anxietyAnxiety, depressionDepression, and other behavioral disorders, in addition to cognitive impairment.

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Formaldehyde Exposure Leads to Circadian Rhythm, Anxiety, Depression, and Other Neuropsychiatric Disorders

  • 章节

  • 发表日期：

    2025年

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  • Xiumei Wang,
  • Shirui Huo,
  • Ying Liu,
  • Yan Wei,
  • Rongqiao He

摘要

Epidemiological studies have demonstrated that individuals exposed to formaldehydeFormaldehyde exhibit a range of neuropsychiatric symptoms, encompassing disturbances in circadian rhythm, disrupted sleep patterns, anxietyAnxiety, depressionDepression, and anorexia. Meta-analyses and bioinformatics methodologies provide compelling evidence and plausible biological explanations for the link between formaldehyde exposure and brain disorders. Except for exogenous exposure, psychiatric disorders may also be associated with endogenous formaldehydeEndogenous formaldehyde accumulation resulting from impaired metabolism induced by aging or diseases. Elevated exogenous or endogenous formaldehydeEndogenous formaldehyde level leads to increased concentrations of formaldehyde (or formic acid) in patients’ urineUrine, which can be used as a predictive marker for certain neuropathological conditions. Herein, we propose that the formaldehyde cycle may act as a regulator of circadian rhythm by influencing the metabolism of melatonin (MT)Melatonin (MT), norepinephrine, epinephrine, and serotonin. The S-adenosyl-L-methionine (SAM)/S-adenosyl-L-homocysteine (SAH) ratio shows circadian rhythms, with formaldehyde acting as a donor of methyl group and participating in the methylation of histone, DNA and RNA. We also discuss the impacts of formaldehyde exposure on psychosomatic and neuropathological behaviorsBehaviors, including sleep disturbances, anxietyAnxiety, depressionDepression, and other behavioral disorders, in addition to cognitive impairment.