Porous structure non-pneumatic tires have the advantages of explosion-proof and impact resistance compared to traditional tires, so they have great application prospects. This paper established a porous structure non-pneumatic tire based on two-dimensional hexagonal honeycomb elements. Combined with the lightweight requirement, the influence of two main structural parameters of hole density and hole wall thickness on tire mechanical characteristics was studied. The result shows that the porous structure tire is more sensitive to load when the density of holes is small, and the tire load characteristics tend to be consistent when the density of holes is large. Moderate hole wall thickness can improve tire tread stress distribution and reduce the maximum tread contact stress value. Combining the two parameters, hole density has a greater influence on vertical displacement and maximum tire tread stress than hole wall thickness. This study provides a foundation for designing non-pneumatic tires with porous structures and studying complex mechanics.