This chapter thoroughly investigates the impact of Ramadan fasting on medication utilization and administration among individuals with chronic illnesses. It underscores the crucial role of healthcare practitioners in formulating individualized healthcare plans to meet the requirements of fasting patients. Understanding the impact of fasting on medication pharmacokinetics and pharmacodynamics is essential for optimizing treatment efficacy and safety. The chapter emphasizes the physiological and pharmacological factors to consider when fasting, such as drug metabolism and absorption alterations. It explores common health issues, including cardiovascular diseases, diabetes, asthma, gastrointestinal disorders, chronic renal disease, mental health disorders, and epilepsy, and their respective management strategies during Ramadan fasting. Healthcare providers are vital in assisting fasting patients by providing education, personalized medication management strategies, and fostering interdisciplinary collaboration. Ethical and religious considerations are also addressed, highlighting the significance of keeping patients’ values while safeguarding their health and welfare.