This document proposes the design and analysis of a piezoelectric energy harvester to be used to power a pacemaker. It is an attempt to replace the traditionally used lead battery-based pacemakers which are bio-incompatible and require frequent surgeries to be replaced. The solution proposed in this document utilizes the heart’s periodic motion to generate energy using a cantilever beam-based piezoelectric energy harvester. Three particular piezoelectric materials were chosen from a literature survey because they proved to be biocompatible. The human heart operates in the range of 1–1.7 Hz. All three of them were simulated to record their voltage response in a wide range of frequencies. Barium titanate (BaTiO3) showed a number of voltage peaks at lower natural frequencies from 100 to 1450 Hz, the highest voltage being 0.146454 V at 100 Hz. Unlike the other two materials which showed a lesser number of prominent voltage peaks. Hence, BaTiO3 proved to be a piezoelectric material that is biocompatible as well as works in the smaller natural frequency range. Further on the dimensions of the cantilever beam and the transducer can be modified to match the frequency range of the human heart.