Biotic stress refers to the altered metabolic status of the plant in response to infestation or infection by a variety of microorganisms, including bacteria, fungi, viruses, pests, and weeds. Biotic stress directly affects the growth and overall health of the host plant such that the host plant is deprived of nutrient access or uptake, leading to loss of vigor and culminating to the death of the plant. Therefore, biotic stress agents jeopardize global food security. The conventional biotic stress agent management strategies include the application of chemical pesticides. However, pesticides seriously harm both human health and the environment. The recent decade witnessed the application of nanoparticles as a promising substitute for chemical pesticides. A variety of nanomaterials have direct pesticidal effects while these can also stimulate localized systemic immune responses in the plant tissues. The latter trait earmarked the role of nanoscale materials as elicitors of immune responses for improved plant health management. This chapter presents the published literature on recent advancements in the application of nanoelicitors for the management of biotic stress agents across various crop plants. Furthermore, different mechanisms of action of the nanoelicitors to enhance crop tolerance and/or resistance to biotic stress have been discussed. The prospects, highlighting the scope of further research to explore the full potential of nanoelicitors in crop health management, have also been discussed.