During the period of the pandemic, COVID-19 swept across the globe and deeply affected the production and performance of most enterprises. Notoriously, innovation has a positive impact on firm revenue, but considering the influence of the pandemic, the result is unknown and worth investigating. To figure out the relationship between corporate innovation and firm revenue, this paper concentrates on the data of some Chinese enterprises during the period of the pandemic, uses the scientific skills of econometrics based on the model of the multivariate linear regression function and chooses revenue over scale as the dependent variable, innovation ability, innovation quality, ESG rating as the independent variables. According to the regression result, this paper reaches an astonishing conclusion that the negative impact of the epidemic on enterprises is far more significant than the positive impact of corporate innovation on firms’ revenue, which means that the more enterprises invest in innovation, the less return they will get. The last part of this paper offers suggestions that can help enterprises change their strategies when faced with inevitable factors.