The chapter on Cognitive Flexibility explains very clearly the meaning, definitions and components of self-regulation such as Awareness, Adaptability, and Confidence. The types and significance of Cognitive flexibility in Communication, Teaching, Creativity, Mental and Physical Health, Health & Wellness, Increased Adaptability, Social Awareness are explained. The meaning and causes of Cognitive Inflexibility is also dealt with in this chapter. Theories of cognitive flexibility, Age and cognitive flexibility and role of brain in cognitive flexibility are clearly presented. How the skill of cognitive flexibility play an important role in Academic achievement is given with suitable examples. The classroom practices include activities for students, adolescents and adults by stressing the importance of Cognitive flexibility training.