The supply chain mainly consists of a complex network of enterprises that operate in various regions and an uncertain and continuously changing environment. Therefore, a large number of risks impact the operation of supply chains. Those actual and potential risks should be efficiently and effectively monitored and managed by supply chain management. Toward the achievement of these targets, the implementation of a well-organized risk management system, the achievement of a high level of integration between supply chain members, and the quick and effective information circulation and dissemination through the extended use of novel digital technologies such as the Internet of Things (IoT), Blockchain and others, are vital. These three concepts are interrelated, and their successful implementation positively influences the supply chain’s risk minimization and operational performance. Grouping risks and developing the appropriate mitigation strategies are essential to identify and keeping risks under control and achieving resilience. In particular, the relevant literature suggests various groups and sub-groups of risks; endogenous/internal and exogenous/external risks are the main categories, and multiple sourcing, high flexibility, and strong collaboration between partners are the most common mitigation strategies. Moreover, emphasis on sustainable objectives and sustainability-related risks is needed. Supply chain operators based on collected and analyzed data with the assistance of new digital technologies and the implementation of the proper management system can successfully manage future risks. The study presents the issues mentioned above easily, clearly, and understandable for readers and provides valuable knowledge to practitioners and academicians.