The development of the Internet of Things (IoT) in recent years has significantly contributed to a paradigm change in all aspects of life. IoT has rapidly gained traction in a short period of time across a variety of sectors, including business, healthcare, governance, infrastructure management, consumer services, and even defense. IoT has the ability to monitor systems through the delivery of consistent and precise information. In medical services it enables us to make decisions, surrounding technologies will play an essential contribution to providing healthcare to people in remote locations. The health centers gather data from areas where cholera has emerged or is suspected, which is then sent to the ministry of public health and population. The World Health Organization in Yemen analyzes the data using two systems (Edews and Ewars), but they lack the full capability for early detection of cholera, and do not utilize Internet of Things technology, which plays an important role in solving most health problems, including cholera. To address this issue, we proposed a framework which consists of six layers and adds parameters that helps early detection of cholera disease. In this study, IoT framework was used for early detection of cholera, thereby assisting the ministry of public health and population and the World Health Organization in making informed decisions by adding the intelligent medical server layer. Overall, this framework is applicable to any field, particularly healthcare for cholera.