This chapter examines the parallels between semantic and biological gene inheritance—specifically, heritability, recombinability, and variability—while highlighting key divergences in temporal–spatial transmission, gene origin, and the demarcation of heritable versus non-heritable units. Prospective applications of semantic-gene repositories span computational systems and traditional linguistic tasks. Such research advances the theoretical understanding of natural-language semantics and furnishes novel methodologies for artificial intelligence and language pedagogy.