The intersection of blockchain technology and knowledge management is changing the way academic content is stored, accessed, and disseminated. This paper explores the potential of NFTs and decentralized architectures to enhance the efficiency and security of knowledge management systems, particularly in academic settings. Traditional knowledge management models, which are reliant on physical and digital repositories, face limitations in accessibility, copyright protection, and data integrity. Blockchain technology offers a secure and transparent method for knowledge transfer and access control, while decentralized approaches such as cloud computing provide scalability and flexibility. Our proposed framework integrates blockchain and NFTs to address these challenges, offering a method for secure and efficient knowledge dissemination. We evaluate the practicality of this framework by implementing smart contracts on four EVM-compatible platforms: Binance Smart Chain, Polygon, Fantom, and Celo. The evaluation assesses the performance, scalability and cost effectiveness of the system.