Vegetables are an essential share of human nutrition globally as they provide essential nutrients, metabolites, and antioxidants. In recent decades, the deleterious impacts of different heavy metals (HMs) contamination on harvests and human fitness are a matter of thoughtful concern. Most prevalent causes of HMs exposure in humans are vegetables, responsible for 90% of metal intake. HMs such as chromium (Cr), cadmium (Cd), lead (Pb), mercury (Hg) copper (Cu), and iron (Fe) are dangerous to both floras and faunas and pose main undesirable impacts on human health. They create severe ecological harms when they are existing in soil. HMs concentration in environment is due to the activities like mining, urbanization, industrialization, transportation, and agronomic operations. They produce a negative effect on the soil’s chemical composition and vegetable nutrients as soil acts as elementary part for plants growing and improvement. Vegetables absorb these dangerous chemicals from the soil along with essential nutrients. There is also a considerable deviation in concentration of the HMs in different regions of the plants and even in several varieties of same species. The feeding of these polluted vegetables inserts severe threats to human health as their persistent and non-degradable nature results in disturbed human metabolism and serious fitness concerns such as cancer, nervous disorders, and renal damage. This chapter effectively explores the lethality of HMs-polluted soils on vegetables and social healthiness as contamination of HMs is a pressing ecological and health issue. Assessment of the contamination of HMs in humans requires a focused investigation. Detection of the heavy metals’ contaminated areas is essential to reduce their negative impact otherwise they may cause dreadful problems in the future. Hyper accumulators like root and stem tubers also need to be regulated by a specific policy to limit the accumulation of HMs in different vegetables. Suitable strategies like pH modifications and phytoremediation technologies should be implemented in agricultural practices to minimize the absorption of heavy metals by vegetables growing in heavy metal-contaminated soils.