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At nearly 1.8 million deaths annually, lung cancer is among the world’s top causes of mortality. Cancer is curable up to a point, after which recovery is extremely challenging. Preventing cancer requires early cancer detection, which localized surface plasmon resonance (LSPR)-based sensors high sensitivity. The phenomenon known as localized surface plasmon resonance (LSPR) occurs when nanoparticles resonate with light at certain wavelengths, leading to the development of characteristics including quick reaction times, adjustable resonance, high sensitivity, and localized light-matter interaction. Since silver-graphene has qualities that make it perfect for cancer detection, it is selected as the material composition. The silver-graphene sensor is utilized for detecting CL1-5 and A549 cell lines, for which the peak of the extinction coefficients was found to be 2.7169 and 1.8592, with a sensitivity of 107 RIU. The Silver-Graphene LSPR sensor interaction with cell lines generated a novel dataset, for which K-Nearest Neighbor Regression has been chosen due to its adaptability and robustness to outliers and has been used to improve the functionality of the sensor by optimizing sensor design, improving sensor sensitivity, and reducing experimental time. With a prediction rate of 99%, KNN and the Silver-Graphene LSPR sensor are an excellent combination for early lung cancer diagnosis.

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K-Nearest Neighbor Optimization of Silver-Graphene Fiber Optic Sensor for Lung Cancer Detection

  • 会议论文

  • 发表日期：

    2025年

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  • Nandan Chebbi,
  • Roshan Balaji Mahashabe,
  • Somesh Nandi,
  • Sandeep Kumar,
  • P. N. Jayanthi,
  • B. Sahana

摘要

At nearly 1.8 million deaths annually, lung cancer is among the world’s top causes of mortality. Cancer is curable up to a point, after which recovery is extremely challenging. Preventing cancer requires early cancer detection, which localized surface plasmon resonance (LSPR)-based sensors high sensitivity. The phenomenon known as localized surface plasmon resonance (LSPR) occurs when nanoparticles resonate with light at certain wavelengths, leading to the development of characteristics including quick reaction times, adjustable resonance, high sensitivity, and localized light-matter interaction. Since silver-graphene has qualities that make it perfect for cancer detection, it is selected as the material composition. The silver-graphene sensor is utilized for detecting CL1-5 and A549 cell lines, for which the peak of the extinction coefficients was found to be 2.7169 and 1.8592, with a sensitivity of 107 RIU. The Silver-Graphene LSPR sensor interaction with cell lines generated a novel dataset, for which K-Nearest Neighbor Regression has been chosen due to its adaptability and robustness to outliers and has been used to improve the functionality of the sensor by optimizing sensor design, improving sensor sensitivity, and reducing experimental time. With a prediction rate of 99%, KNN and the Silver-Graphene LSPR sensor are an excellent combination for early lung cancer diagnosis.