With the evolution of blockchain technology from versions 1.0 to 3.0, its application domain has expanded from a single payment scenario to multiple areas, forming a complex blockchain ecosystem. However, the security issues of this ecosystem are becoming increasingly prominent, necessitating regulation. On the basis of the analysis and summary of the composition of the blockchain ecosystem and its security challenges, we propose a dual-engine-driven framework (DEDF) for blockchain ecosystem security regulation, which conducts security regulations from both business compliance supervision and technical risk assessment. The experimental results show that the proposed framework can efficiently deploy regulatory rules, take effect, and analyze blockchain security risks in a timely manner, meeting security regulation needs under various user scales and application scenarios. In short, we provide a high-level framework for blockchain ecosystem regulation for academia and industry.