There is no such thing as a safe drug in either allopathic or traditional medicine. No matter how often a medicine is used in the clinic, it can still hurt someone. It is true that side effects are a part of modern medicine, but traditional medicines, especially plant medicines (phytomedicines), also use drugs that are not really safe. The majority of the people in both developed and developing nations use these plant-based remedies to maintain their health. People who manufacture and use traditional drugs claim that human testing is unnecessary because these substances have been used for centuries. In their ancient recipes, it is stated that medications prepared in this manner are harmless. In reality, however, not all pharmaceuticals are produced in the same manner. Due to intense competition and the scarcity of high-quality raw materials, not all medicines are manufactured in accordance with the standards established by drug regulatory bodies. Anything that does not follow the official pharmacopoeias could lead to harmful effects. There have also been a number of other high-profile safety concerns about herbs in recent years that have had an impact on public health. It is becoming clear that herbal medicines need to have Pharmacovigilance systems put in place. It can be challenging to do drug surveillance for herbal drugs or keep an eye on how safe they are. The goal of this chapter is to give a full and critical picture of how Pharmacovigilance activities for herbal drugs are progressing at the national and international levels at present. It will delve into description about the hurdles that come up with Pharmacovigilance for herbal medicines. It will also take a look at new issues that are important and what could and should be done to make safety tracking for herbal medicines better in the future. Along with this, exhaustive data about the Pharmacovigilance program for AYUSH drugs, such as Unani, is also included.