Arsenic, a naturally occurring mineral, occurs in a wide range of natural environments. A thorough review of arsenic uptake, toxicity, and tolerance processes in agricultural plants is given in this chapter, along with management techniques for soils contaminated by arsenic. Arsenic poses serious threats to both agricultural productivity and human health. The first section covers the arsenic uptake mechanisms of plants and their effects on plant physiology. The chapter also includes plants’ genetic and biochemical processes for arsenic resistance. Additionally, the chapter highlights the use of phytoremediation to reduce arsenic toxicity. The chapter also looks at soil management techniques like applying amendments and using bioremediation techniques to improve soil health and reduce arsenic bioavailability. By integrating data from toxicology, plant physiology, and soil science, this chapter aims to provide a thorough understanding of arsenic dynamics in agriculture and practical solutions for farmers and land managers dealing with arsenic contamination.