The focus on “inclusion” in the Sustainable Development Goals (SDGs) underscores the worldwide initiative to promote social, economic, and political integration among diverse groups of people. Despite progress in reducing extreme poverty, issues such as rising income inequality and the exclusion of vulnerable groups, including migrants, refugees, ethnic minorities, women, and people with disabilities, persist. In Africa, where approximately 15 percent of the population lives with disabilities, understanding the intersection of disability with factors such as gender, age, ethnicity, and socioeconomic status is critical for addressing the unique challenges faced by individuals with disabilities. The disability rights movement in Africa has grown significantly, advocating for greater inclusion and influencing policy decisions. Data collection on people with disabilities has provided valuable insights into the disparities they face, particularly in employment, education, and poverty. This chapter explores the concept of disability-inclusive development, which addresses the compounded discrimination that people with disabilities experience due to intersecting factors such as gender and ethnicity. Focusing on key areas like inclusive education, employment, healthcare, and accessibility, the twin-track approach to disability-inclusive development ensures that people with disabilities are active participants and beneficiaries in the development process. This approach is essential to ending extreme poverty and promoting social inclusion while also highlighting the need for context-specific strategies to address the diverse needs of individuals with disabilities across regions. Through a multifaceted approach that combines global commitments with local solutions, the chapter underscores the importance of disability-inclusive development in creating equitable opportunities for all.