Oral appliances for the treatment of snoring and obstructive sleep apnea (OSA) are defined as devices intended to protrude and stabilize the mandible in order to maintain a patent airway during sleep. Currently, oral appliances are indicated for mild to moderate OSA patients who are not indicated for or cannot tolerate continuous positive airway pressure (CPAP). Although oral appliances are less efficacious in reducing AHI in comparison with CPAP, they are generally well tolerated. The greater efficacy of CPAP is interpreted to offset by inferior adherence relative to oral appliances, suggesting consequently similar effectiveness in comparison with CPAP in OSA treatment. Titration of oral appliance, in which mandibular position is incrementally advanced ventrally until resolution of OSA symptoms and respiratory events, is a key to optimize its efficacy. As oral appliance therapy is a lifelong treatment option for individuals with OSA, every sleep dentist should not overlook short-term side effects that could turn into irreversible long-term adverse consequences. Success in the interdisciplinary management of OSA can be achieved through constant communication and follow-up with the sleep physician and sleep dentist.