The burgeoning space tourism industry highlights the dire but understudied psychological challenges civilians traveling beyond Earth face. Unlike trained astronauts, space tourists face novel stressors, such as isolation, confinement, circadian misalignment, and the overwhelming “overview effect”—the fundamental shift in worldview that can occur upon seeing Earth from low-Earth orbit. In this chapter, we articulate these psychological barriers and suggest a framework to ensure psychological health that might include a triadic structure: pre-flight preparation (for instance, virtual reality simulations, psychological screening), in-flight support (AI companions and tele-psychiatry), and post-flight reintegration (counselling and peer networks). It emphasizes the need for resilience-building strategies to counteract risk factors like anxiety, existential dissonance, or crises of identity. The findings could have implications for space tourism and mental health care in extreme terrestrial environments. Focusing on the mental well-being of innovators, not just the technical revolution, will lead to lasting and sustainable success and promote compassion and environmental awareness worldwide. Space tourism is an emerging field that presents unique psychological stressors, making mental resilience and robust support systems essential.