Space tourism creates new healthcare challenges that have never been encountered before in space’s unique and extreme environment, such as microgravity, cosmic radiation, and isolation. Traditional medical systems tailored to terrestrial conditions are not well-equipped to address these hazards effectively. For this purpose, we closely examine how AI and advanced medical technologies can change how healthcare is delivered to space tourists. AI-facilitated diagnostics allow for near-identical biometric monitoring and predictive analysis that currently occur on Earth, and telemedicine helps to patch any comms gaps with Earth-side specialists for assistance. Augmented reality (AR) and virtual reality (VR) allow non-medically trained crews to conduct complicated procedures, and 3D printing enables on-demand production of medical instruments and pharmaceuticals, alleviating payload limitations. Radiation-hardened AI systems and ethical dilemmas around algorithmic decision-making pose technical challenges that need solid solutions. The advances made in space healthcare may have incredible potential on Earth, particularly in underserved populations and in remote areas, which, in turn, drive global health equity. Incorporating technological adaptability, ethical governance, and cross-system synergies in a sustainable framework, this chapter presents sustainable paradigms that improve the safety of the human factor in space missions and promote the mutation of this knowledge to Earth medicine. The relationships between these technologies highlight the dual-use potential of space-derived innovations that may enable improved access to and delivery of healthcare services, either in a low-gravity environment or on the surface of the Earth, where health disparities exist. This chapter provides that the impact of space-driven technologies in one domain may help justify expansion into the other domain and thus address such disparities.