This chapter investigates the interface of healthcare and metaverse; here we have emphasized the evolution of business models in Meta-Health. Here we have discussed the healthcare business models by exploring their scope and limitations; we have also discussed the transformative impact of the metaverse on healthcare delivery, along with emerging advanced business systems. The chapter explores the key aspects of Meta-Health business models by including a range of topics including identification of target audience, market analysis, technological advancement, and legal and ethical aspects. Subsequently, we examined the new business models for Meta-Health that can be delivered virtually through healthcare platforms and wellness experiences. Further, we have summarized challenges and future trends that can impact Meta-Health’s business models. Throughout this exploration, this chapter helps to understand the emerging technologies in metaverse and outlines the strategies for the advanced healthcare landscape.