Nature provides many medicinal plants that act as biological factories of diverse groups of metabolites, including alkaloids. One of the well-known and earliest reported classes of natural secondary metabolites belongs to alkaloids, nitrogen-containing heterocyclic compounds, with diverse biological and pharmacologically active, especially neurological disorders. The major source for the tropane alkaloids belongs to Solanaceae, a botanical family with many subgroups. Tropane alkaloids have been thoroughly investigated, utilized in numerous pharmacological procedures, and employed in the creation of beneficial medicinal substances. As parasympatholytics that competitively inhibit acetylcholine, tropane alkaloids are advantageous. These alkaloids are based on the bicyclic ring of the tropane moiety, and the majority of tropane alkaloids are ester derivatives that are substituted on the atom C-3 of the tropane ring. The present revision focuses on the chemistry of tropane alkaloids and their possible biological resources that might be helpful to scientists to study further and develop nontoxic and safe medicaments.