In order to meet the challenge of developing a dummy spleen model, the stress–strain curves at different loading speeds were obtained through animal spleen mechanics experiments. A continuum medium mechanical model was used to accurately fit the biomechanical parameters of spleen, and PVC material with similar mechanical properties of spleen was selected. Based on these parameters, a highly simulated spleen model was made and compared with the real spleen. The results show that PVC bionic spleen exhibits the same mechanical response as real spleen during compression and stretching, which provides an accurate spleen model for biomechanical research and clinical application.