Drought and heat stress present formidable challenges to global food production systems and food security, especially in the wake of climate change. Cognizant of this, there is a need to explore various options for their mitigation to reduce abiotic plant stress. Rhizobacteria are plant-root-residing bacteria that establish intimate relations with their host plants and provide them with several benefits, such as abiotic stress tolerance. Thus, rhizobacteria can be explored as environmentally friendly option for drought and heat stress mitigation in plants. This chapter presents the potential of rhizobacteria for drought and heat stress mitigation in common food crops from a global perspective. This chapter first unravels the impacts of drought and heat stress on crop plants and provides insights into rhizobacteria-mediated stress mitigation. This chapter also encompasses the multifarious mechanisms through which rhizobacteria enhance plant resistance to drought and heat stress, from the alleviation of oxidative stress to the regulation of phytohormones, and the challenges and future directions regarding this potential. This chapter includes recent research reports to shed light on the potential of rhizobacteria-mediated drought and heat stress mitigation in agriculture. This chapter also highlights the urgency of harnessing these beneficial microbes to ensure sustainable crop production and enhance global food security. By exploring the potential of rhizobacteria for drought and heat stress mitigation in plants, this chapter provides a comprehensive understanding of their potential in promoting the resilience of agricultural ecosystems, to ensure food production in a constantly changing climate which is anticipated to become harsher for crop production.