The Biomimetic hydrogel composite structures based on micro/nanocellulose have been developed through various techniques for biomedical, soft robotics and energy storage applications. Owing to the unique native properties of cellulose such as biocompatibility, biodegradability and excellent mechanical properties, it offers new strategies for the design of environmentally friendly and cost-effective and high mechanical performance composite 3D printed composite hydrogel. Herein, we proposed the fabrication of nature-inspired 3D printed cellulose nanofibers (CNF) based anisotropic functional fibre reinforced hydrogel composite structure and performed its physical and mechanical characterisations. In this work, we proposed to develop 3D-printed multilayered Polyacrylamide (PAAM)/Alginate (Alg) hydrogel based CNF reinforced mechanically robust functional composite hydrogel structures. In this study, our main focus was to perform finite element (FE) models via implementing measured experimental material properties to explore the CNF reinforcement mechanism in the fiber reinforced composite hydrogel. The FE modelling is based on an idealised anisotropic hyperelastic model was used to analyse the pre-programmed anisotropic functional composite structure with the computer simulations. It is shown how the improved mechanical and physical properties of the hydrogel fiber reinforced composite printed scaffold can be programmed by varying cellulose fibers/fibrils orientation and matrix compliance, making it suitable for load bearing biomedical applications. We propose that the computational study of the nature-inspired 3D printed helicoidally layup construct based on PAAM/Alg/CNF composite, which offered appreciable stretchability and enhanced anisotropic mechanical properties, will assist the design of more effective composite structure, offering new perspectives for potential application in tissue engineering.