Hydrogels, remarkable for mimicking the properties of living tissues, are finding widespread use in biomedical applications like tissue engineering, drug delivery, and biosensing. This review study compiles recent studies on the tribological characteristics of polymer nanocomposites incorporating Hydroxyapatite (HAP), Graphene (Gr) and calcium phosphate (CaP). It was observed that the addition of HAP increases the amount of HAP in cell culture scaffolds surges the elastic modulus, cell adhesion and viability which has been shown in numerous investigations which significantly enhance tensile and flexural strength of polymer composites. However, Poly (ethylene glycol) diacrylate Graphene (PEGDA/Gr) shows the maximum amount of compressive strength with a 150.3% increase over unfilled PEGDA. Observing many of the research studies are being carried out, it is seen that the Gr and CaP can support cellular development and showed similar biocompatibility. Various tests such as Micro-CT ant the Rheological tests were carried out to see the cell growth and their composition under appropriate environment. It can be concluded that various micro/nano fillers increase the mechanical and tribological properties of hydrogel nanocomposites. This review study will pave a way to design and develop mechanically robust Hydrogels nanocomposites in the bio-medical field such as in bone cartilage and tricuspid heart valve and drug delivery.