Stress is a pervasive challenge for students in health professions education, arising from rigorous academic demands, clinical responsibilities, and personal life imbalances. This chapter explores the multifaceted nature of stress in health professions education, emphasizing its causes, manifestations, and management strategies. High expectations, perfectionism, and imposter syndrome often exacerbate stress, leading to psychological and academic struggles. Clinical training, financial pressures, and sociocultural issues further contribute to students’ stress, impacting their emotional, physical, and interpersonal well-being. Common symptoms include decreased academic performance, depression, anxiety, fatigue, and strained relationships. To address these challenges, this chapter highlights comprehensive strategies to mitigate stress. Time management, mindfulness practices, self-care, and social support are pivotal in fostering resilience among students. Professional interventions, such as counseling and wellness programs, combined with cognitive behavioral techniques, can further enhance coping abilities. Academic strategies, including active learning and effective study techniques, aim to alleviate stress while supporting academic success. Emphasizing work-life balance, setting boundaries, and engaging in creative outlets also contribute to holistic well-being. By fostering supportive environments and equipping students with essential coping mechanisms, educational institutions can enhance learners’ well-being, academic performance, and readiness for professional roles in the demanding field of healthcare.