A 9-month-old male infant with a heart murmur was diagnosed with moderate-to-severe tricuspid regurgitation (TR) and scheduled to undergo tricuspid valve plasty under general anesthesia. The patient experienced right heart failure during weaning from cardiopulmonary bypass (CPB). After an optimal adjustment of ventilation parameters and positive inotropic drugs, the right ventricle function was improved, and the infant was successfully weaned from CPB. The keys to anesthetic management during valvuloplasty surgery in a TR child include maintaining sufficient right ventricular preload before CPB, reducing pulmonary vascular resistance, and maintaining myocardial contractility. Due to the increased pressure and volume load on the right ventricle, attention should be paid to the possible occurrence of right heart failure.