Aiming at the problems of low flow control accuracy, slow response and large energy loss in existing crane load-sensitive systems, a crane pressure-flow composite control electro-hydraulic system based on pressure/flow mode switching and bilinear interpolation flow control strategy is proposed. According to the working conditions, the pump and valve are combined with pressure and flow sensitivity. During micro-movement, the flow compensator dynamically adjusts the valve opening according to the real-time pressure difference before and after the valve port to achieve precise flow control. During rapid movement, the valve port is fully opened and the hydraulic pump adjustment system is used. flow. This article establishes the AMESim simulation model of the system and builds a pump-valve collaborative test platform. The control characteristics of the constructed system under constant pressure difference and varying flow rates were investigated through simulation and experimental analysis. Additionally, the system’s behavior was examined under different pressure differences while maintaining a constant flow rate. The research results show that when the pressure-flow composite control electro-hydraulic system is in micro-flow (≤ 70 L/min), the fluctuation of the flow during the dynamic change of the load is not greater than 10.98%, which can effectively suppress the disturbance of the flow caused by the load change. When the present pressure difference of the pump control subsystem increases, the system responds quickly and has high dynamic performance. When the present pressure difference decreases, the system flow control accuracy can be improved.