To address the issue of center of mass variation in heavy vehicles equipped with active suspension under different operating conditions, this study pro-poses a measurement method based on active suspension. The X and Y coordinates of the vehicle’s center of mass are measured using a four-wheel weighing method, while the Z coordinate is determined using a weight response method. This weight response method compensates for the limitation of the four-wheel weighing method, which cannot measure the Z-direction center of mass coordinate. The measurement error for the X-direction center of mass coordinate obtained from the four-wheel weighing method is within 8 mm, and within 12 mm for the Y-direction. For the Z-direction coordinate, the weight response method yields a measurement error within 14 mm. Experimental results demonstrate that the proposed center of mass measurement method effectively addresses the control performance issues arising from center of mass variations, thereby offering potential improvements in the ride comfort and handling stability of vehicles with active suspension.