The interconnection mode of the hydraulic system of a 130 t five-axle all-terrain crane with independent suspension is investigated in this paper. The two-degree-of-freedom vehicle dynamics for completely independent, front and rear interconnection, and front and rear to side cross-linked hydro-pneumatic suspensions are modeled. A whole vehicle hydraulic system model of hydro-pneumatic suspension is built by using AMESim software. Two different random road spectra are inputted and the root mean square (RMS) values of body acceleration, suspension dynamic deflection, and tire dynamic load are compared for the three cases. It is demonstrated by the analysis results that a front and rear interconnected hydro-pneumatic suspension system in the independent suspension hydraulic system of all-terrain cranes is more advantageous than the other two hydraulic systems in terms of ride smoothness and comfort.