To that extent, this chapter presents an account of the innovative application of nanotechnology in sports medicine and probably the most effective nano-nutrients for athletes craving for superior performance as invincible immune shields. This leads to an increase immunosuppression and susceptibility to diseases owing to rigorous physical exerted put on athletes. Nano-nutrients, that is nutrients that are nanoscaled, will present enhanced immunology performance and bioavailabilityBioavailability (enhanced), site of action targeting the cells of interest and up to 90% absorptionAbsorption rates; this is a novel strategy towards enhancing immune strength. Something that will be seen as one of the main top line benefitsBenefits of nanotechnology in relation with nutrient delivery has to do with supporting the cell, repairing and protecting it from oxidative damage. This chapter also discusses the progress achieved in the past few years in the encapsulation of vitamins, mineralsMinerals and bioactive compoundsBioactive compounds into nanoparticles for the abilityAbility of the later to affect immune responses and inflammationInflammation as well as oxidation stress. Nano enhanced antioxidantsAntioxidants as described in the previous chapters are beneficial in reversing oxidative damage that is caused by exercisesExercise which help to maintain muscle strengths and shortened recovery time. The incorporation of nanotech into sports nutrition provides one of the best ways toward supporting the athlete’s immune system and maintain the bodyBody and mind’s consistently in great performance conditions. Based on the findings of the latest scientific advances from the field of sports immunology and nanotechnology this chapter offers a critical analysis of the opportunities for the use of nanotechnology as a key to enhance the healthHealth, longevity and performance of the athletes.