Nanotechnology has emerged as a transformative force in the field of electrolyteElectrolytes replacement with exceptional advancements. This chapter explores the juncture between electrolyteElectrolytes therapy and nanotechnology, offering an exhaustive analysis of leading-edge, ground breaking and emergent materials that have revolutionized the critical area of medicine and healthcare. The book begins by explaining the physiological significance of electrolytesElectrolytes and their pivotal role in maintaining homeostasis. It also highlights the drawbacks of traditional electrolyteElectrolytes replacement therapies which includes inadequacy in bioavailability, delivery efficiencyEfficiency and side effects. In light of this, the discussion of how crucial nanotechnology is to overcome these barriers are further discussed. Nanostructured materials like nanoparticles, nano sheets and nano gels which plays imperative role in precise and targeted deliveryTargeted delivery (liposomes, polymeric nanoparticles) of electrolytesElectrolytes to bodyBody are discussed in this chapter. Improved physiological processes by using artificial membranes or replicating original ones via nano engineered ion channels and artificial membranes are introduced later in chapter.