Over the last few years, Artificial Intelligence (AI) has developed faster, and more applications have been recognized in various industries, including the hotel industry. This study analyzes the impact that AI has on hotel management, its application, and the challenges it faces. A bibliometric and content analysis was applied, allowing us to analyze the evolution of scientific production and the most relevant thematic topics. This research reveals that AI has influenced hotel domains such as guest satisfaction, cleaning issues, and employee satisfaction and skills. The last domain through the literature has caused some problems for hotel managers, for instance, an increase in employee turnover and higher levels of burnout among staff. However, the financial sustainability and the optimization of resources are highlighted as advantages of AI use. This study provides a set of AI technologies applied in hotels, as well as the challenges of hoteliers. Managing the interaction between humans and AI is crucial to have success of the implementation of AI in the hotel industry.