The Shaximiao tight sandstone gas reservoir in Block H is characterized by shallow buial, thin thickness and low porosity and permeability. Initially, vertical well tubing fracturing was adopted for reservoir stimulation, but factors such as small construction scale, poor reservoir properties, and low pressure coefficients led to rapid production decline, making it challenging to achieve cost-effective development. In recent years, attempts have been made to conduct horizontal well volume fracturing trials to increase production. Given the large amount of fracturing fluid required for horizontal well fracturing, challenges such as difficulties in post-fracturing flowback, damage to the reservoir, and high construction costs have emerged. Therefore, the research primarily focuses on reducing the amount of fracturing fluid and improving fracturing efficiency. The transformation concept of “large-segment with multi-cluster close cutting + fluid control and sand increase + real-time temporary plugging” has been established. Optimization of segment cluster division, fracturing fluid system, proppant combination, and key construction parameters is conducted through numerical simulation and well data. In addition, the wide field electromagnetic monitoring method is used to guide real-time temporary plugging technology on site, ensuring uniform frature initiation and extension among multiple clusters. High-frequency pressure monitoring systems are utilized to collect real-time pressure data for analyzing fracture morphology and evaluating reservoir modification, achieving efficient transformation of large-segment multi-cluster horizontal well. The Q101 well has undergone fracturing modification using the above techniques, with 8 segments and 54 clusters fractured, a sand-to-fluid ratio of 1:7, and temporary plugging in 6 intervals. Post-fracturing testing has achieved a daily production of 18.62 × 104m3, marking a new breakthrough in post-fracturing production in the H Block Shaximiao reservoir. This research provides valuable insights for the development of horizontal wells in similar tight sandstone gas reservoirs.