The occurrence of condensate oil and gas in reservoirs is complex, which is easily affected by changes of reservoir fluids and pressure. Currently, the dominant role of affecting retrograde condensation and condensate volume is not certain. Fracture treatment is always adopted in low permeable condensate reservoirs. Once temperature and pressure of reservoir is lower than the dewpoint during flowback, condensate gas always occur retrograde condensation which will lead to hydrocarbon lock and water lock. As a result, production reduces rapidly. In order to study the affecting factors of chemical agents for condensate reservoirs and its damage mechanism, experiments have been carried out on damages to reservoir caused by condensate oil saturation and water lock of fracture fluids and compatibility of fracture fluids and reservoir. The experimental results will offer appropriate fracture treatments for condensate reservoir.