Aiming at the deeper stratigraphy of Dengying Formation in Sichuan area and the existence of water layer at the bottom, which makes it difficult to carry out effective reservoir transformation, this paper proposes and implements the method of fine optimization of reservoir transformation parameters and optimization of transformation technology scheme based on the integrated study of geo-engineering. Using drilling and recording side, 3D seismic and other data, the tectonic model is finely established, and on the basis of the tectonic model, a high-quality reservoir spreading is engraved, using imaging logging data and seismic data reprocessing to characterize the distribution of natural fractures around the wells, and the geological model is coupled with the finite-element geomechanical model, to analyze the characteristics of the open natural fractures, and the optimization of the transformation parameters and scheme for the open natural fractures, to obtain a high-yielding industrial well.