This chapter explores the application of behavioral computing in addressing human factor security and safety in production. Section 9.1 systematically analyzes the internal and external threat scenarios encountered in safe production, including risks such as human error, malicious intrusion, and advanced persistent threats (APTs). Section 9.2 reviews methods for detecting internal threats based on behavioral analysis, alongside techniques for detecting external threats such as intrusions and malicious activities. Section 9.3 presents case studies to illustrate the practical application and optimization strategies of these detection methods in real-world production environments. Section 9.4 summarises the challenges faced by existing detection approaches and proposes improved solutions integrating behavioral computing, offering new insights to enhance human factor security and safety in production.