Metabolic and bariatric surgery (MBS) especially for the first 6 postoperative months contributes to varied nutrient deficiencies due to multiple factors. The most common deficiencies post-MBS are that of iron, vitamin A, vitamin B12, vitamin D, calcium, and protein, though other nutrient deficiencies like zinc, magnesium, copper, selenium, vitamin K, and vitamin E are not uncommon. Close monitoring along with ideal supplementation is mandatory especially in this phase. Since micronutrient deficiencies are common after MBS, it is important to screen them prior to surgery and periodically after surgery. A suggestion for post-op lab screening may include, at a minimum, quarterly for the first year, half yearly at the second year, and then annually thereafter. Adherence with any multivitamin supplement regimen after MBS can be difficult due to the number of supplements recommended and the available formulations. Due to increased transit of ingested contents and poor absorption capacity, over-the-counter supplements are not completely effective for patients post-MBS. There is increased absorption of vitamins and minerals through ready-to-eat, ready-to-mix and chewable supplements as the micronutrients begin to be broken down before they reach absorption sites. The supplements must have the highest bioavailability and be from natural/organic sources wherever possible. For these reasons, specific salts have better bioavailability to reduce postoperative deficiencies. The vitamins as citrates and glauconite salts are the best for patients post-MBS. Chelated minerals are available in supplements and have better absorption and bioavailability. An “all inclusive” supplement improves adherence by decreasing the number of pills patients need to take to help prevent the risk of developing nutritional deficiencies from the beginning. Importantly, supplements should not be enteric coated or time release formulations, as most patients have diminished gastric phase digestion. Supplements and medications should readily dissolve in a glass of room temperature water and absorbed within 20 min once ingested. The required volume in tablet form for the recommended daily doses is impractical and may lead to decreased adherence. Alternative forms like liquid, suspension, or chewable preparations are better received over tablets. In the early postoperative months, liquids and chewable preparations are often better tolerated. Among these, dissolvable supplements in a powder form may be better as they help in hydration, which can be a major concern in the first few weeks post-surgery.