This research explores the potential of combining phase change materials (PCMs) with ventilation control strategies to reduce overheating risks in newly constructed dwellings. In such buildings, adverse summer comfort conditions can emerge due to the retention of heat within their highly insulated and sealed envelopes. By passively integrating PCMs alongside night ventilation strategies, cool outdoor air can dissipate the heat energy stored in PCMs, facilitating their melting and solidification cycles and harvesting their full potential. In this study, a residential building integrated with PCMs is subjected to three different ventilation strategies to evaluate the impact on PCM performance. Simulations were conducted for various cities to assess the climate dependency of the results. The findings demonstrate that PCM technology, when combined with appropriate ventilation strategies, effectively reduces overheating hours. In Brussels and Stockholm, PCM integration alone was sufficient to prevent overheating in the building. In contrast, in cities with higher outdoor air temperatures, such as Madrid and Vienna, a proper ventilation strategy is necessary to mitigate the relatively high number of overheating hours. In these cities, overheating hours were reduced by 14.3–16.2%.