Reducing the environmental impact of human activities within the Architecture, Engineering, and Construction (AEC) industry is a major concern worldwide. This article critically examines the potential for sustainable building design through the aggregation of solid voxels and the 3D modeling of digital mock-ups at varying levels of automation. The aim of this methodology is to maintain the designer’s creativity by leveraging the strengths of these paradigms. To do so, the construction processes are broken down according to a manufacturing nomenclature whose data is established from the “analogon” of the project, thus enabling an automatic life cycle assessment (LCA). The estimates provided by this model, simulated based on information available during the sketch design phase, are then discussed in comparison with the results obtained from seven real projects. An error of less than 5% demonstrates the effectiveness of the multi-scale evaluation framework of the proposed methodology. Finally, it can be stated that, given the information available during the final design phase, the LCA obtained is in accordance with the relevant regulations.