In achieving climate neutrality, holistic energy efficiency strategies for industrial real estate are necessary. Considering long-term impacts on the building performance is required when comparing retrofit alternatives with life cycle assessments (LCAs). However, the influence of dynamic time-dependent factors in the LCA of industrial building retrofits remains inadequately explored. This study addresses this gap by assessing the Global Warming Potential (GWP) of a synthetic industrial building’s operational phase under different retrofits while considering dynamic electricity mix and climate change. Our findings highlight a minor impact of climate change on overall operational GWP due to low heating energy relative to other energy usage in the industrial facility. In contrast, dynamically adapted electricity mix scenarios significantly influence the overall GWP of the industrial facility’s operations until 2050, indicating a need to reassess retrofit decision-making processes.