Industry 5.0 represents a paradigm shift from the automation and efficiency focus of Industry 4.0 to a more human-centric approach, emphasizing integrating such advanced technologies as AI and robotics with human skills and creativity. The PRISMA framework provides a systematic, transparent, reproducible review process to build a comprehensive understanding of balancing human-centered innovation with technology and leadership in Industry 5.0. This approach accords with the decision of the most relevant, high-quality studies but also documents the research process accurately to enhance the review’s credibility. This paper delves into the importance of balancing technological advances and leadership in Industry 5.0, emphasizing human-centric innovation. The paper articulates how organizational setups will use technology to empower the workforce, unleash productivity, and create a competitive, workable, inclusive environment. The paper concludes by outlining strategies the leader can adopt to navigate this change effectively.