Histoplasmosis, caused by the dimorphic environmental fungus Histoplasma capsulatum, is a major mycosis on the global stage. Acquisition of the fungus by mammalian hosts can be clinically silent or lead to life-threatening systemic disease. In most cases, affected individuals are often asymptomatic, but 1% may present symptoms associated with the infection. Symptomatic patients usually present symptoms within 1–3 weeks from exposure, progressing to develop fever, chills, dry cough, chest pain, myalgias, and headaches, often described as a flu-like syndrome. Therefore, this study is aimed to present a challenging case report of Histoplasma capsulatum infection.