This chapter reviews the advanced technology of Opto-Hydrodynamic Manipulation, which elegantly combines optical and fluid dynamic principles to achieve precise control over microscale objects. The chapter begins by introducing the definition, significance, and historical context of opto-hydrodynamic manipulation, emphasizing its wide-ranging applications in fields such as biomedicine, nanotechnology, and microengineering. It then delves into the principles of optical forces arising from light-matter interaction, microscale fluid dynamics, and the theoretical frameworks of combined opto-hydrodynamic effects. The technological foundations, including optical tweezers and microfluidic systems, are discussed in detail, along with the latest advancements in light-induced hydrodynamic manipulation. The chapter highlights advanced applications in biomedicine and nanotechnology, such as light-induced cold Marangoni flow, 3D dynamic microswarm petals, and the opto-hydrodynamic diatombot. Finally, the chapter discusses the challenges and future directions of opto-hydrodynamic manipulation, including technical, biological, and medical challenges, as well as potential future research directions. This chapter aims to provide a comprehensive overview of the field of opto-hydrodynamic manipulation, showcasing its potential in scientific research and technological innovation.