In order to further achieve lightweight satellite structures, this paper focuses on the design of a panelized satellite main structure. A topology optimization method based on fundamental frequency optimization is employed, alongside the utilization of a lattice structure for variable density filling. This approach not only meets the required strength criteria but also reduces the overall structural weight. Numerical simulation analysis techniques are utilized to conduct static and modal analyses of the designed configuration. The study investigates the load-bearing and vibrational characteristics of the panelized satellite structure. Analysis and discussions are provided on the results of static analysis, load-bearing performance, confirming the feasibility of the designed satellite main structure.